Reprogramming the Human Genome

Data Guided Control


The work in our lab is focused on the dynamics of genome organization in human cells, with emphasis on gaining a deeper understanding of how the cell cycle guides cell fate determination. We are developing genomic and imaging technologies for determining the natural dynamics of the cell cycle and building a data guided mathematical foundation. Our long term goal is to develop strategies for direct reprogramming of normal and abnormal cells

Principal Investigator: Indika Rajapakse
Lab Manager: Walter Meixner
Postdoctoral Researchers: Haiming Chen
Ph.D. Students: Scott Ronquist, Stephen Lindsly, Emily Crossette ,
Can Chen
Undergraduate Students: Cyrus Najarian

Ph.D. Graduates: Laura Seaman (now at Draper Laboratory)
Past Postdoctoral Researchers: Sijia Liu, Jie Chen
Honorary Lab Member: Stephen Smale


Fall 2017: Bioinformatics 540 / Math 540: Mathematics of Biological Networks (PDF)
Winter 2018: Bioinformatics / Math 547: Probabilistic Modeling in Bioinformatics (PDF)


Defense Advanced Research Research Projects Agency
Air Force Office of Scientific Research
Smale Institute of Mathematics and Computation


Data-Guided Control
4D Nucleome
"Science of Me" education initiative with Leland Hartwell

Conferences & Workshops

Extended Workshop: Genome/Cell/Tissues


The Collected Papers of Stephen Smale
Papers by our lab members

Contact Information

Department of Computational Medicine & Bioinformatics
1600 Huron Parkway, NCRC Building 520
Rm. 3392
Ann Arbor, MI 48105